The burden of heart failure (HF), developing after myocardial infarction MI, still represents a
major issue in clinical practice. Failure of appropriate resolution of inflammation during post …

Among the various immunological and non-immunological tumor-promoting activities of
myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a …

Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) have been
recognized as a promising cell-free therapy for acute kidney injury (AKI), which avoids safety …

The mammalian target of rapamycin (mTOR) pathway regulates major processes by
integrating a variety of exogenous cues, including diverse environmental inputs in the tumor …

Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their
inhibition is critical for successful cancer immunotherapy. MDSCs undergo metabolic …

The aging process is associated with chronic low-grade inflammation in both humans and
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …

Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently,
there are no targeted therapeutics for preventing and treating AKI. Macrophages, important …

Despite the remarkable success and efficacy of immune checkpoint blockade (ICB) therapy
such as anti-PD-L1 antibody in treating cancers, myeloid-derived suppressor cells (MDSCs) …

Ferroptosis is an iron-dependent programmed cell death associated with severe kidney
diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial …