Ketamine recently approved for therapy of treatment-resistant depression shows a complex
and not fully understood mechanism of action. Apart from its classical glutamatergic N …

This article provides an updated review of the pharmacological profile and available efficacy
and tolerability/safety data for vilazodone, one of the most recent antidepressant drugs to be …

Morinda officinalis oligosaccharides (MOs) are natural herbal extracts that have been shown
to exert antidepressant effects. However, the mechanism of this effect remains unclear. Here …

Affecting up to 15% of older adults, late-life depression (LLD) is characterized by the
occurrence of depressive symptoms after the age of 50–65 years and maybe …

Background: Geriatric depression is a heterogeneous disorder that increases morbidity and
mortality in a population that is already vulnerable. Predicting response and remission to …

Affective disorders (AD) including major depressive disorder (MDD) and bipolar disorder
(BD) are common mood disorders associated with increased disability and poor health …

Variation in the expression level and activity of genes involved in drug disposition and action
in tissues of pharmacological importance have been increasingly investigated in patients …

ABSTRACT Introduction: Major Depressive Disorder (MDD) and General Anxiety Disorder
(GAD) significantly contribute to the global burden of disease. Vilazodone, a combined …

Various types of adaptive behavior during the prepubertal period were analyzed in the
offspring of rats receiving chronic injections of serotonin (5-HT) reuptake inhibitor fluoxetine …

Introduction Geriatric depression is frequently accompanied by cognitive complaints and
inflammation that increase risk for treatment-resistant depression and dementia. Memantine …