Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

ATJ Murk, E Rijntjes, BJ Blaauboer, R Clewell… - Toxicology in vitro, 2013 - Elsevier
The thyroid hormone (TH) system is involved in several important physiological processes,
including regulation of energy metabolism, growth and differentiation, development and …

Thyroid and corticosteroid signaling in amphibian metamorphosis

B Paul, ZR Sterner, DR Buchholz, YB Shi, LM Sachs - Cells, 2022 - mdpi.com
In multicellular organisms, development is based in part on the integration of communication
systems. Two neuroendocrine axes, the hypothalamic–pituitary–thyroid and the …

[HTML][HTML] More similar than you think: Frog metamorphosis as a model of human perinatal endocrinology

DR Buchholz - Developmental biology, 2015 - Elsevier
Hormonal control of development during the human perinatal period is critically important
and complex with multiple hormones regulating fetal growth, brain development, and organ …

Insufficiency of thyroid hormone in frog metamorphosis and the role of glucocorticoids

LM Sachs, DR Buchholz - Frontiers in Endocrinology, 2019 - frontiersin.org
Thyroid hormone (TH) is the most important hormone in frog metamorphosis, a
developmental process which will not occur in the absence of TH but can be induced …

ERGO: Breaking down the wall between human health and environmental testing of endocrine disrupters

H Holbech, P Matthiessen, M Hansen… - International journal of …, 2020 - mdpi.com
ERGO (EndocRine Guideline Optimization) is the acronym of a European Union-funded
research and innovation action, that aims to break down the wall between mammalian and …

Remarkable metabolic reorganization and altered metabolic requirements in frog metamorphic climax

W Zhu, L Chang, T Zhao, B Wang, J Jiang - Frontiers in Zoology, 2020 - Springer
Background Metamorphic climax is the crucial stage of amphibian metamorphosis
responsible for the morphological and functional changes necessary for transition to a …

Unliganded Thyroid Hormone Receptor α Regulates Developmental Timing via Gene Repression in Xenopus tropicalis

J Choi, KT Suzuki, T Sakuma, L Shewade… - …, 2015 - academic.oup.com
Thyroid hormone (TH) receptor (TR) expression begins early in development in all
vertebrates when circulating TH levels are absent or minimal, yet few developmental roles …

Staging and normal table of postembryonic development of the clownfish (Amphiprion ocellaris)

N Roux, P Salis, A Lambert, V Logeux… - Developmental …, 2019 - Wiley Online Library
Abstract Background The clownfish Amphiprion ocellaris is one of the rare coral reef fish
species that can be reared in aquaria. With relatively short embryonic and larval …

Life without thyroid hormone receptor

YB Shi - Endocrinology, 2021 - academic.oup.com
Thyroid hormone (T3) is critical not only for organ function and metabolism in the adult but
also for animal development. This is particularly true during the neonatal period when T3 …

The multi-level regulation of clownfish metamorphosis by thyroid hormones

N Roux, S Miura, M Dussenne, Y Tara, S Lee… - Cell reports, 2023 - cell.com
Most marine organisms have a biphasic life cycle during which pelagic larvae transform into
radically different juveniles. In vertebrates, the role of thyroid hormones (THs) in triggering …