Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …

In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …

The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine
mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion …

Ferroptosis is an iron-driven cell death modality characterized by iron accumulation and
excessive lipid peroxidation. Ferroptosis is closely related to mitochondrial function, as …

Membrane dynamics are important to the integrity and function of mitochondria. Defective
mitochondrial fusion underlies the pathogenesis of multiple diseases. The ability to target …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial
function and quality control. Mitochondrial fusion and division are integrated into diverse …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …

Abstract Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating
mitochondrial fusion and cell metabolism. Mutations in MFN2 cause the neurodegenerative …