The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Protein arginine transferase 5 (PRMT5) has been implicated as an important modulator of
tumorigenesis as it promotes tumor cell proliferation, invasion, and metastasis. Studies have …

PRMT5 is a major enzyme responsible for symmetric dimethylation of arginine residues on
both histone and non-histone proteins, regulating many biological pathways in mammalian …

Rationale: Protein arginine methyltransferase 5 (PRMT5) is an oncogene that promotes
tumor cell proliferation, invasion and metastasis. However, the underlying mechanisms by …

In recent years, protein arginine methyltransferases (PRMTs) have emerged as new
members of a gene expression regulator family in eukaryotes, and are associated with …

Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetric dimethylation (SDM) of
arginine, a posttranslational modification involved in oncogenesis and embryonic …

Regulatory T cells (Tregs) are a subpopulation of T cells that are specialized in suppressing
immune responses. Here we show that the arginine methyl transferase protein PRMT5 can …

The methylation of arginine residues in proteins is a post-translational modification that
contributes to a wide range of biological processes. Many cytokines involved in T cell …

A remarkable post-transitional modification of both histones and non-histone proteins is
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …