Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is
induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to …

Blood transfusion is an essential and irreplaceable part of modern medicine, as a
therapeutic modality or additional support to other clinical therapies. Nevertheless, the entire …

Prestorage filtration of blood to remove contaminating donor leukocytes and platelets has
substantially increased the safety level of transfusion therapy. We have previously shown …

Background The association between perioperative blood transfusion and the prognosis of
patients with gastric cancer is still unclear. Methods A total of 1581 patients with gastric …

Red blood cell (RBC) transfusions may have a negative impact on the prognosis of patients
with cancer, where transfusion‑related immunomodulation (TRIM) may be a significant …

Simple Summary In head and neck cancer surgery, blood transfusion is required
occasionally due to patients' underlying conditions and perioperative blood loss during …

Red blood cells supply the oxygen required for all human cells and are in demand for
emerging blood-loss therapy. Here we identified N6-methyl-2′-deoxyadenosine (6mdA) as …

Red blood cells (RBCs) capability to deliver oxygen (O2) has been routinely measured by
P50. Although this defines the ability of RBCs to carry O2 under equilibrium states, it cannot …