DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to
the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family …

The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively
spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are …

Two non-covalently linked copies of the retrovirus genome are specifically recruited to the
site of virus particle assembly and packaged into released particles. Retroviral RNA …

During HIV infection, specific RNA-protein interaction between the Rev response element
(RRE) and viral Rev protein is required for nuclear export of intron-containing viral mRNA …

The HIV-1 Rev response element (RRE) RNA element mediates the nuclear export of intron
containing viral RNAs by forming an oligomeric complex with the viral protein Rev. Stem IIB …

Viruses remain a global threat to animals, plants, and humans. The type 1 human
immunodeficiency virus (HIV-1) is a member of the retrovirus family and carries an RNA …

HIV-1 requires a specialized nuclear export pathway to transport unspliced and partially
spliced viral transcripts to the cytoplasm. Central to this pathway is the viral protein Rev …

DEAD/DEAH-box helicases are enzymes that belong to the DEAD/H-box family of SF2
helicase superfamily. These enzymes are essential in RNA metabolism, where they are …

HIV-1 Rev mediates the nuclear export of unspliced and partially-spliced viral transcripts for
the production of progeny genomes and structural proteins. In this process, four (or more) …

72a Sunday, February 12, 2017 the viral mRNA. In order to activate nuclear export, multiple
Rev proteins must assemble on the RRE. The host DEAD box protein 1 (DDX1) enhances …