5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …

Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

The concept that G protein‐coupled receptors (GPCRs) can form hetero‐dimers or hetero‐
oligomers continues to gain experimental support. However, with the exception of the …

G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …

Although the cardinal manifestations of Parkinson's disease (PD) are attributed to a decline
in dopamine levels in the striatum, a breadth of non-motor features and treatment-related …

The traditional view on GPCRs held that they function as single monomeric units composed
of identical subunits. This notion was overturned by the discovery that GPCRs can form …