Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic
review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept …

This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF).
Evidence for reductions in O2 content (CaO2) rather than arterial O2 tension (PaO2) as the …

Decreased cerebrovascular blood flow and function are associated with lower cognitive
functioning and increased risk of neurodegenerative diseases. Prolonged sitting impairs …

Regulation of the cerebral circulation relies on the complex interplay between
cardiovascular, respiratory, and neural physiology. In health, these physiologic systems act …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Intermittent fasting and exercise provide neuroprotection from age‐related cognitive decline.
A link between these two seemingly distinct stressors is their capability to steer the brain …

Background Exogenous ketones make it possible to reach a state of ketosis that may
improve metabolic control in humans. Objectives The main objective of this study was to …

Key points Brachial artery (BA) shear‐mediated dilatation is a widely used assessment of
vascular function with links to coronary artery health and cardiovascular risk. Cerebral …

Cerebrovascular CO2 reactivity (CVR) is often considered a bioassay of cerebrovascular
endothelial function. We recently introduced a test of cerebral shear‐mediated dilatation …

Increases in arterial carbon dioxide tension (hypercapnia) elicit potent vasodilation of
cerebral arterioles. Recent studies have also reported vasodilation of the internal carotid …