There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …

Cancer risk reduction using pharmacological means is an attractive modern preventive
approach that supplements the classical behavioural prevention recommendations …

Objective The aim of this study was to explore the relationship between statin use and the
risk of pancreatic cancer. Methods Electronic databases were searched to identify relevant …

BACKGROUND Statins are cholesterol‐lowering medications with pleiotropic effects,
including alterations in growth signaling, as well as immunomodulatory and anti …

Background Interactions of inflammatory cells with pancreatic cancer cells play crucial roles
in pancreatic cancer, however the dynamic changes of inflammatory cell populations in …

Statins are widely used drugs for their role in decreasing cholesterol in
hypercholesterolemic patients. Statins through inhibition of Hydroxy Methyl Glutaryl-CoA …

Background Previous studies investigating the association between statin use and
pancreatic cancer (PDAC) risk for a possible chemopreventive effect gathered …

Pancreatic ductal adenocarcinoma (PDAC) is expected to soon become the second leading
cause of cancer related deaths in the United States. This may be due to the rising obesity …

Statins, besides being powerful cholesterol-lowering drugs, also exert potent anti-
proliferative activities. However, their anti-cancer efficacy differs among the individual …

Purpose Statins are commonly prescribed medications that potently reduce cholesterol
levels and the risk of cardiovascular events. Preclinical studies suggested statins also …