This review focuses on discussing the main changes on the upcoming fourth edition of the
WHO Classification of Tumors of the Pituitary Gland emphasizing histopathological and …

Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome characterized by the co-
occurrence of primary hyperparathyroidism, duodenopancreatic neuroendocrine tumours …

Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors
(PitNET), are mostly benign, but may present various behaviors: invasive,“aggressive” and …

Background Germline pathogenic variants in SDHB/SDHC/SDHD are the most frequent
causes of inherited phaeochromocytomas/paragangliomas. Insufficient information …

Phaeochromocytoma and paraganglioma (PHEO/PGL) are rare tumours with an estimated
annual incidence of 3 per million. Advances in molecular understanding have led to the …

Importance Effective cancer prevention is based on accurate molecular diagnosis and
results of genetic family screening, genotype-informed risk assessment, and tailored …

Substantial advances have been made recently in the pathobiology of pituitary tumors.
Similar to many other endocrine tumors, over the last few years we have recognized the role …

Paragangliomas (PGL) develop from the parasympathetic system in the head and neck (HN)
and arise primarily in four distinct areas: Carotid body, vagal, middle ear, and larynx …

Medullary thyroid carcinomas (MTC) arise from thyroid parafollicular, calcitonin-producing C-
cells and can occur either as sporadic or as hereditary diseases in the context of familial …