Synthesis of polyheterocycles via multicomponent reactions

IA Ibarra, A Islas-Jácome… - Organic & Biomolecular …, 2018 - pubs.rsc.org
Polyheterocycles are one of the most desired synthetic targets due to their numerous and
valuable applications in various fields. Multicomponent reactions (MCRs) are highly …

The Ugi three-component reaction and its variants

JC Flores-Reyes, A Islas-Jácome… - Organic Chemistry …, 2021 - pubs.rsc.org
More than 60 years have passed since I. Ugi synthesized the first α-amidoamides in one
experimental step involving a combination of aldehydes, amines, carboxylic acids and …

The Groebke‐Blackburn‐Bienaymé Reaction

A Boltjes, A Dömling - European Journal of Organic Chemistry, 2019 - Wiley Online Library
Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

Metal–organic framework MIL-101 (Cr) as an efficient heterogeneous catalyst for clean synthesis of benzoazoles

E Niknam, F Panahi, F Daneshgar, F Bahrami… - ACS …, 2018 - ACS Publications
A metal–organic framework [MIL-101 (Cr)] was used as an efficient heterogeneous catalyst
in the synthesis of benzoazoles (benzimidazole, benzothiazole, and benzoxazole), and …

Synthesis of heterocyclic analogs of isoflavone and homoisoflavone based on 3-formylchromone

SS Shatokhin, VA Tuskaev, SC Gagieva… - Russian Chemical …, 2021 - Springer
The review is focused on recent developments of chemistry of synthetic analogs of natural
compounds, isoflavone and homoisoflavone. The possible synthetic strategies to access …

One‐Pot Construction of Bis‐Heterocycles through Isocyanide Based Multicomponent Reactions

S Ishwar Bhat - ChemistrySelect, 2020 - Wiley Online Library
Bis‐heterocycles (BHCs) are hybrid molecules comprising two linked, bound, spacer, or
fused heterocyclic skeletons. In recent years, these compounds have attracted increased …

α-Aminoazoles/azines: key reaction partners for multicomponent reactions

S Imtiaz, S Banoo - RSC advances, 2021 - pubs.rsc.org
Aromatic α-aminoazaheterocycles are the focus of significant investigations and exploration
by researchers owing to their key role in diverse biological and physiological processes. The …

Solvent- and Catalyst-Free One-Pot Green Bound-Type Fused Bis-Heterocycles Synthesis via Groebke–Blackburn–Bienaymé Reaction/SNAr/Ring-Chain Azido …

MA Claudio-Catalán, SG Pharande… - ACS …, 2018 - ACS Publications
A new, efficient, green, endogenous water-triggered, solvent-and catalyst-free ultrasound-
assisted one-pot Groebke–Blackburn–Bienaymé reaction/SNAr/ring-chain azido …

An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction

SG Balwe, YT Jeong - Organic & biomolecular chemistry, 2018 - pubs.rsc.org
A concise and efficient one-pot synthesis of novel N-fused tricyclic derivatives has been
developed by using the Groebke–Blackburn–Bienaymé (GBB) reaction, which involved the …

On water catalyst-free synthesis of benzo [d] imidazo [2, 1-b] thiazoles and novel N-alkylated 2-aminobenzo [d] oxazoles under microwave irradiation

N Mukku, B Maiti - RSC advances, 2020 - pubs.rsc.org
A highly efficient unprecedented catalyst-free microwave-assisted procedure for
synthesizing benzo [d] imidazo [2, 1-b] thiazoles and N-alkylated 2-aminobenzo [d] oxazol in …