Regulation and functions of non-m6A mRNA modifications
Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …
resulted in the emergence of epitranscriptomics as a research field. The most abundant …
Gene regulation in the immune system by long noncoding RNAs
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination
Abstract N 6-methyladenosine (m6A), the most abundant internal messenger RNA
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …
RNA editing underlies genetic risk of common inflammatory diseases
A major challenge in human genetics is to identify the molecular mechanisms of trait-
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …
5-methylcytosine promotes mRNA export—NSUN2 as the methyltransferase and ALYREF as an m5C reader
methylcytosine (m 5 C) is a post-transcriptional RNA modification identified in both stable
and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in …
and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in …
A-to-I RNA editing—immune protector and transcriptome diversifier
E Eisenberg, EY Levanon - Nature Reviews Genetics, 2018 - nature.com
Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …
modifications because it not only alters the cellular fate of RNA molecules but also alters …
The novel roles of circRNAs in human cancer
Covalently closed single-stranded circular RNAs (circRNAs) consist of introns or exons and
are widely present in eukaryotic cells. CircRNAs generally have low expression levels and …
are widely present in eukaryotic cells. CircRNAs generally have low expression levels and …
Landscape of adenosine-to-inosine RNA recoding across human tissues
O Gabay, Y Shoshan, E Kopel, U Ben-Zvi… - Nature …, 2022 - nature.com
RNA editing by adenosine deaminases changes the information encoded in the mRNA from
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …
A-to-I editing of coding and non-coding RNAs by ADARs
K Nishikura - Nature reviews Molecular cell biology, 2016 - nature.com
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-
stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but …
stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but …
Next-generation sequencing in oncology: genetic diagnosis, risk prediction and cancer classification
R Kamps, RD Brandão, BJ van den Bosch… - International journal of …, 2017 - mdpi.com
Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …