Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …

Abstract N 6-methyladenosine (m6A), the most abundant internal messenger RNA
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …

A major challenge in human genetics is to identify the molecular mechanisms of trait-
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …

methylcytosine (m 5 C) is a post-transcriptional RNA modification identified in both stable
and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in …

Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Covalently closed single-stranded circular RNAs (circRNAs) consist of introns or exons and
are widely present in eukaryotic cells. CircRNAs generally have low expression levels and …

RNA editing by adenosine deaminases changes the information encoded in the mRNA from
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-
stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but …

Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …