Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …

The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …

Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a
group of phenotypically diverse genetic disorders known as laminopathies, which have …

Emery‐Dreifuss muscular dystrophy (EDMD) is a rare muscular dystrophy, but is particularly
important to diagnose due to frequent life‐threatening cardiac complications. EDMD …

Mutations in LMNA, the gene that encodes A-type lamins, cause multiple diseases including
dystrophies of the skeletal muscle and fat, dilated cardiomyopathy, and progeria-like …

Progeria: A Paradigm for Translational Medicine: Cell Skip to Main Content Advertisement Cell
This journal offers authors two options (open access or subscription) to publish research This …