Covalent fragment approaches combine advantages of covalent binders and fragment-
based drug discovery (FBDD) for target identification and validation. Although early …

Inspired by nature's wide range of oxidation-induced modifications to install cross-links and
cycles at tyrosine (Tyr) and other phenol-containing residue side chains, we report a Tyr …

Establishing analytical and functional comparability serves as the foundation of biosimilar
development. A critical part of this exercise is sequence similarity search and categorization …

New methods for chemo-selective modifications of peptides and native proteins are
important in chemical biology and for the development of therapeutic conjugates. Less …

Labelling of tyrosine residues in peptides and proteins has been reported to selectively
occur via a 'tyrosine-click'reaction with triazolinedione reagents (TAD). However, we here …

Here, we first report a rapid and highly selective biocompatible ligation that proceeds via a
strain-promoted prenyl-involved [2, 3]-Ene rearrangement process. We demonstrate the …

The present study introduces a TiO 2 nanoparticle-based (TiO 2-NP) system for the
generation of• OΗ and O 2•− upon visible photo-excitation, in order to be used for high …

Hydrogels based on renewable resources are a promising class of materials for future
applications in pharmaceutics, drug delivery and personalized medicine. Thus, optional …

Preventing lipid oxidation at the oil-water interface is critical for suppressing food emulsion
deterioration and thus minimizing the economy loss. However, it is challenging to …

COVID-19 is a rapidly evolving emergency, which necessitates scientific community to come
up with novel formulations that could find quick relief to the millions affected around the …