Electrical microstimulation has enabled partial restoration of vision, hearing, movement,
somatosensation, as well as improving organ functions by electrically modulating neural …

Brain–machine interfaces (BMIs) aim to treat sensorimotor neurological disorders by
creating artificial motor and/or sensory pathways. Introducing artificial pathways creates new …

Deep brain stimulation (DBS) is a promising neuromodulation therapy, but the
neurophysiological mechanisms of DBS remain unclear. In awake mice, we performed high …

In Parkinson's disease (PD), the loss of midbrain dopaminergic cells results in severe
locomotor deficits, such as gait freezing and akinesia. Growing evidence indicates that these …

Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …

Due to the prevalence of chronic pain worldwide, there is an urgent need to improve pain
management strategies. While opioid drugs have long been used to treat chronic pain, their …

Parkinson's disease (PD) relates to defective mitochondrial quality control in the
dopaminergic motor network. Genetic studies have revealed that PINK1 and Parkin …

Objective. Neural prosthetics often use intracortical microstimulation (ICMS) for sensory
restoration. To restore natural and functional feedback, we must first understand how …

Exploring the relationship between neuronal dynamics and ethologically relevant behaviour
involves recording neuronal-population activity using technologies that are compatible with …

Accelerating technological progress in experimental neuroscience is increasing the scale as
well as specificity of both observational and perturbational approaches to study circuit …