Background: The connection between uric acid (UA) and renal impairment is well known
due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging …

Abstract Purpose of Review In chronic kidney disease (CKD), plasma uric acid levels are
increased because of the decrease in glomerular filtration rate. However, in addition to CKD …

The relationship between hyperuricemia, gout, and renal disease has been investigated for
several years. From the beginning, kidney disease has been considered a complication of …

Background Hyperuricemic nephropathy may be induced by the elevation and accumulation
of uric acid in kidney after hyperuricemia, which leads to kidney residential cells apoptosis …

We reviewed all currently available ULT, as well as any medications in development using
following databases: United States Food and Drug Administration (FDA), European …

Hyperuricemia is common in chronic kidney disease (CKD) and may be present in 50% of
patients presenting for dialysis. Hyperuricemia can be secondary to impaired glomerular …

Ethnopharmacological relevance Hyperuricemic nephropathy (HN) is a renal injury caused
by hyperuricemia and is the main cause of chronic kidney disease and end-stage renal …

The reabsorption of uric acid (UA) is mainly mediated by urate transporter 1 (URAT1) and
glucose transporter 9 (GLUT9) in the kidneys. Dotinurad inhibits URAT1 but does not inhibit …

РЕЗЮМЕ Цель исследования: определить вероятность достижения целевого уровня
мочевой кислоты (МК) при проведении терапии фебуксостатом в таблетированной …

Although chronic kidney disease (CKD) is recognized as a major public health concern,
effective treatment strategies have yet to be developed. Identification and validation of drug …