The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in
TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of …

p53 mutations are found in 50% of human cancers. Molecular epidemiology has shown
strong correlations between the spectrum of p53 mutations and exposure to exogenous …

Objective: Controversy concerning cancer incidence in schizophrenia exists because of
heterogeneous study findings. Method: A meta‐analysis was performed on standardized …

The etiology of schizophrenia is thought to include both epistasis and gene-environment
interactions. We sought to test whether a set of schizophrenia candidate genes regulated by …

AKT1-dependent molecular pathways control diverse aspects of cellular development and
adaptation, including interactions with neuronal dopaminergic signaling. If AKT1 has an …

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway
is critical to cell growth and survival. In vitro functional studies indicate that the candidate …

The tumor suppressor gene TP53 is the most frequently mutated gene in human cancer; this
gene is subject to inactivation by mutation or deletion in> 50% of sporadic cancers. Genes …

A paper by Bond et al. reported that a single-nucleotide polymorphism (SNP) in the intronic
promoter region of the mouse double minute 2 (MDM2) gene (called SNP309) can …

Purpose: Non–small cell lung cancer (NSCLC) metastasizes fairly often to the brain, but
identifying which patients will develop brain metastases is problematic. The …

The D2/AKT1/GSK-3β signaling pathway has been involved in the downstream intracellular
effects of dopamine, in the pathophysiology of cognitive deficits and related brain activity in …