Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes

M Julià‐Sapé, JR Griffiths, RA Tate… - NMR in …, 2015 - Wiley Online Library
The INTERPRET project was a multicentre European collaboration, carried out from 2000 to
2002, which developed a decision‐support system (DSS) for helping neuroradiologists with …

Anti‐tumour immune response in GL261 glioblastoma generated by Temozolomide Immune‐Enhancing Metronomic Schedule monitored with MRSI‐based …

S Wu, P Calero‐Pérez, L Villamañan… - NMR in …, 2020 - Wiley Online Library
Glioblastomas (GB) are brain tumours with poor prognosis even after aggressive therapy.
Improvements in both therapeutic and follow‐up strategies are urgently needed. In previous …

Metronomic treatment in immunocompetent preclinical GL261 glioblastoma: effects of cyclophosphamide and temozolomide

L Ferrer‐Font, N Arias‐Ramos… - NMR in …, 2017 - Wiley Online Library
Glioblastoma (GBM) causes poor survival in patients even when applying aggressive
treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment …

Convex non-negative matrix factorization for brain tumor delimitation from MRSI data

S Ortega-Martorell, PJG Lisboa, A Vellido, RV Simões… - 2012 - journals.plos.org
Background Pattern Recognition techniques can provide invaluable insights in the field of
neuro-oncology. This is because the clinical analysis of brain tumors requires the use of non …

MRSI‐based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis

T Delgado‐Goñi, S Ortega‐Martorell… - NMR in …, 2016 - Wiley Online Library
Characterization of glioblastoma (GB) response to treatment is a key factor for improving
patients' survival and prognosis. MRI and magnetic resonance spectroscopic imaging …

Molecular imaging coupled to pattern recognition distinguishes response to temozolomide in preclinical glioblastoma

T Delgado‐Goñi, M Julià‐Sapé… - NMR in …, 2014 - Wiley Online Library
Non‐invasive monitoring of response to treatment of glioblastoma (GB) is nowadays carried
out using MRI. MRS and MR spectroscopic imaging (MRSI) constitute promising tools for this …

Metabolomics of therapy response in preclinical glioblastoma: A multi-slice MRSI-based volumetric analysis for noninvasive assessment of temozolomide treatment

N Arias-Ramos, L Ferrer-Font, S Lope-Piedrafita… - Metabolites, 2017 - mdpi.com
Glioblastoma (GBM) is the most common aggressive primary brain tumor in adults, with a
short survival time even after aggressive therapy. Non-invasive surrogate biomarkers of …

In Vivo Detection of Perinatal Brain Metabolite Changes in a Rabbit Model of Intrauterine Growth Restriction (IUGR)

RV Simões, E Muñoz-Moreno, RJ Carbajo… - PLoS …, 2015 - journals.plos.org
Background Intrauterine growth restriction (IUGR) is a risk factor for abnormal
neurodevelopment. We studied a rabbit model of IUGR by magnetic resonance imaging …

Short TE downfield magnetic resonance spectroscopy in a mouse model of brain glioma

SI Gonçalves, RV Simões… - Magnetic Resonance in …, 2022 - Wiley Online Library
Purpose Enhanced cell proliferation in tumors can be associated with altered metabolic
profiles and dramatic microenvironmental changes. Downfield magnetic resonance …

Dimethyl sulfoxide (DMSO) as a potential contrast agent for brain tumors

T Delgado‐Goñi, J Martín‐Sitjar, RV Simoes… - NMR in …, 2013 - Wiley Online Library
Dimethyl sulfoxide (DMSO) is commonly used in preclinical studies of animal models of high‐
grade glioma as a solvent for chemotherapeutic agents. A strong DMSO signal was detected …