Roles of PIKfyve in multiple cellular pathways
P Rivero-Ríos, LS Weisman - Current Opinion in Cell Biology, 2022 - Elsevier
Phosphoinositide signaling lipids are crucial for eukaryotes and regulate many aspects of
cell function. These signaling molecules are difficult to study because they are extremely low …
cell function. These signaling molecules are difficult to study because they are extremely low …
Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases
Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …
Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway
M Tufail, JJ Hu, J Liang, CY He, WD Wan… - Journal of Translational …, 2024 - Springer
Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …
Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize …
EJ Choi, HT Oh, SH Lee, CS Zhang, M Li, SY Kim… - Autophagy, 2024 - Taylor & Francis
Co-occurring mutations in KEAP1 in STK11/LKB1-mutant NSCLC activate NFE2L2/NRF2 to
compensate for the loss of STK11-AMPK activity during metabolic adaptation …
compensate for the loss of STK11-AMPK activity during metabolic adaptation …
PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells
Although PIKFYVE phosphoinositide kinase inhibitors can selectively eliminate PIKFYVE-
dependent human cancer cells in vitro and in vivo, the basis for this selectivity has remained …
dependent human cancer cells in vitro and in vivo, the basis for this selectivity has remained …
Pressure sensing of lysosomes enables control of TFEB responses in macrophages
R Cai, O Scott, G Ye, T Le, E Saran, W Kwon… - Nature Cell …, 2024 - nature.com
Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable
solutes. While the transport of diverse organic solutes across the plasma membrane is well …
solutes. While the transport of diverse organic solutes across the plasma membrane is well …
A guide to membrane atg8ylation and autophagy with reflections on immunity
The process of membrane atg8ylation, defined herein as the conjugation of the ATG8 family
of ubiquitin-like proteins to membrane lipids, is beginning to be appreciated in its broader …
of ubiquitin-like proteins to membrane lipids, is beginning to be appreciated in its broader …
Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2V617F myeloproliferative neoplasms
C Courdy, L Platteeuw, C Ducau, I De Araujo… - Blood Cancer …, 2023 - nature.com
Abstract The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are
chronic malignancies associated with high-risk complications and suboptimal responses to …
chronic malignancies associated with high-risk complications and suboptimal responses to …
The regulatory mechanism and therapeutic potential of transcription factor EB in neurodegenerative diseases
F Jiao, B Zhou, L Meng - CNS Neuroscience & Therapeutics, 2023 - Wiley Online Library
The autophagy‐lysosomal pathway (ALP) is involved in the degradation of protein
aggregates and damaged organelles. Transcription factor EB (TFEB), a major regulator of …
aggregates and damaged organelles. Transcription factor EB (TFEB), a major regulator of …