Phosphoinositide signaling lipids are crucial for eukaryotes and regulate many aspects of
cell function. These signaling molecules are difficult to study because they are extremely low …

Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …

Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …

Co-occurring mutations in KEAP1 in STK11/LKB1-mutant NSCLC activate NFE2L2/NRF2 to
compensate for the loss of STK11-AMPK activity during metabolic adaptation …

Although PIKFYVE phosphoinositide kinase inhibitors can selectively eliminate PIKFYVE-
dependent human cancer cells in vitro and in vivo, the basis for this selectivity has remained …

Polymers are endocytosed and hydrolysed by lysosomal enzymes to generate transportable
solutes. While the transport of diverse organic solutes across the plasma membrane is well …

The process of membrane atg8ylation, defined herein as the conjugation of the ATG8 family
of ubiquitin-like proteins to membrane lipids, is beginning to be appreciated in its broader …

Abstract The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are
chronic malignancies associated with high-risk complications and suboptimal responses to …

The autophagy‐lysosomal pathway (ALP) is involved in the degradation of protein
aggregates and damaged organelles. Transcription factor EB (TFEB), a major regulator of …