One of the most significant problems facing developmental biologists who do not work on an
organism with well-developed genetics-and even for some who do-is how to inhibit the …

▪ Abstract Embryological and genetic studies of mouse, bird, zebrafish, and frog embryos are
providing new insights into the regulatory functions of the myogenic regulatory factors …

The mammalian genome harbors up to one million regulatory elements often located at
great distances from their target genes. Long-range elements control genes through …

Long-range regulatory interactions play an important role in shaping gene-expression
programs. However, the genomic features that organize these activities are still poorly …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

In vertebrates, skeletal muscle is a model for the acquisition of cell fate from stem cells. Two
determination factors of the basic helix–loop–helix myogenic regulatory factor (MRF) family …

Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on
cell morphology, phenotype, or select functional properties. However, these attributes are …

Unraveling the complex tissue interactions necessary to generate the structural and
functional diversity present among craniofacial muscles is challenging. These muscles …

Skeletal muscle has an intrinsic capacity for regeneration following injury or exercise. The
presence of adult stem cells in various tissues with myogenic potential provides new …

During limb development, coordinated expression of several Hoxd genes is required in
presumptive digits. We searched for the underlying control sequences upstream from the …