Transforming growth factor beta (TGF-β) is a pleiotropic cytokine with dual role in
hepatocellular carcinoma (HCC). It acts as tumor-suppressor and tumor-promoter in the …

Existing preclinical models of human colorectal cancer (CRC) that rely on syngeneic
subcutaneous grafts are problematic, because of increasing evidence that the immune …

In this paper a new methodology to detect and differentiate melanoma cells from normal
cells through 1D-signatures averaged variances calculated with a binary mask is presented …

Microenvironment and tumor aggressiveness recruitment of inflammatory cells is well known
to support aggressive tumor behavior. In particular, macrophages play a physiologic role in …

Initiation of the desmoplastic reaction associated with cancer depends on PDGF (Shao et al.,
2000). Similarly, PDGF is one of the most potent chemoattractants and activators of …

Background: This thesis uses PET imaging to explore the use of 11C-acetate, a radiotracer
that maps fatty acid synthesis, as a predictive imaging biomarker of radioresistance in …

Glioblastoma (GBM) is the most common and malignant form of human primary brain tumor.
Due to its extremely malignant and invasive nature, the mean survival period of GBM …

This invention relates to the modulation of DNA repair and nucleic acid editing mechanisms
for use in the treatment of cancer. This invention relates to the inactivation of DNA repair and …

Glioblastoma Multiforme (GBM) is the most common and malignant form of the primary brain
tumor. Due to its highly invasive nature, current treatment options have not been able to …