The multiple sclerosis prodrome

N Makhani, H Tremlett - Nature Reviews Neurology, 2021 - nature.com
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …

From the prodromal stage of multiple sclerosis to disease prevention

RA Marrie, M Allegretta, LF Barcellos, B Bebo… - Nature Reviews …, 2022 - nature.com
A prodrome is an early set of signs or symptoms that indicate the onset of a disease before
more typical symptoms develop. Prodromal stages are well recognized in some neurological …

[HTML][HTML] How does neurovascular unit dysfunction contribute to multiple sclerosis?

JM Cashion, KM Young, BA Sutherland - Neurobiology of Disease, 2023 - Elsevier
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
(CNS) and the most common non-traumatic cause of neurological disability in young adults …

Microbiome in multiple sclerosis: Where are we, what we know and do not know

MK Boziki, E Kesidou, P Theotokis, AFA Mentis… - Brain sciences, 2020 - mdpi.com
An increase of multiple sclerosis (MS) incidence has been reported during the last decade,
and this may be connected to environmental factors. This review article aims to encapsulate …

[HTML][HTML] Leptomeningeal enhancement in multiple sclerosis and other neurological diseases: A systematic review and Meta-Analysis

BV Ineichen, C Tsagkas, M Absinta, DS Reich - NeuroImage: Clinical, 2022 - Elsevier
Background The lack of systematic evidence on leptomeningeal enhancement (LME) on
MRI in neurological diseases, including multiple sclerosis (MS), hampers its interpretation in …

Biochemically altered myelin triggers autoimmune demyelination

AV Caprariello, JA Rogers… - Proceedings of the …, 2018 - National Acad Sciences
Although immune attack against central nervous system (CNS) myelin is a central feature of
multiple sclerosis (MS), its root cause is unresolved. In this report, we provide direct …

The multiple sclerosis prodrome: Emerging evidence, challenges, and opportunities

H Tremlett, RA Marrie - Multiple Sclerosis Journal, 2021 - journals.sagepub.com
A prodrome is considered an early set of signs or symptoms indicating the onset of a
disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years …

Embedding electronic health records onto a knowledge network recognizes prodromal features of multiple sclerosis and predicts diagnosis

CA Nelson, R Bove, AJ Butte… - Journal of the American …, 2022 - academic.oup.com
Objective Early identification of chronic diseases is a pillar of precision medicine as it can
lead to improved outcomes, reduction of disease burden, and lower healthcare costs …

Revisiting the pathoetiology of multiple sclerosis: has the tail been wagging the mouse?

MK Sen, MSM Almuslehi, PJ Shortland… - Frontiers in …, 2020 - frontiersin.org
Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …

Differential impact of environmental factors on systemic and localized autoimmunity

H Touil, K Mounts, PL De Jager - Frontiers in immunology, 2023 - frontiersin.org
The influence of environmental factors on the development of autoimmune disease is being
broadly investigated to better understand the multifactorial nature of autoimmune …