The multiple sclerosis prodrome
N Makhani, H Tremlett - Nature Reviews Neurology, 2021 - nature.com
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …
typical symptoms of a disease. Prodromal phases are well recognized in several …
From the prodromal stage of multiple sclerosis to disease prevention
RA Marrie, M Allegretta, LF Barcellos, B Bebo… - Nature Reviews …, 2022 - nature.com
A prodrome is an early set of signs or symptoms that indicate the onset of a disease before
more typical symptoms develop. Prodromal stages are well recognized in some neurological …
more typical symptoms develop. Prodromal stages are well recognized in some neurological …
[HTML][HTML] How does neurovascular unit dysfunction contribute to multiple sclerosis?
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
(CNS) and the most common non-traumatic cause of neurological disability in young adults …
(CNS) and the most common non-traumatic cause of neurological disability in young adults …
Microbiome in multiple sclerosis: Where are we, what we know and do not know
An increase of multiple sclerosis (MS) incidence has been reported during the last decade,
and this may be connected to environmental factors. This review article aims to encapsulate …
and this may be connected to environmental factors. This review article aims to encapsulate …
[HTML][HTML] Leptomeningeal enhancement in multiple sclerosis and other neurological diseases: A systematic review and Meta-Analysis
Background The lack of systematic evidence on leptomeningeal enhancement (LME) on
MRI in neurological diseases, including multiple sclerosis (MS), hampers its interpretation in …
MRI in neurological diseases, including multiple sclerosis (MS), hampers its interpretation in …
Biochemically altered myelin triggers autoimmune demyelination
AV Caprariello, JA Rogers… - Proceedings of the …, 2018 - National Acad Sciences
Although immune attack against central nervous system (CNS) myelin is a central feature of
multiple sclerosis (MS), its root cause is unresolved. In this report, we provide direct …
multiple sclerosis (MS), its root cause is unresolved. In this report, we provide direct …
The multiple sclerosis prodrome: Emerging evidence, challenges, and opportunities
H Tremlett, RA Marrie - Multiple Sclerosis Journal, 2021 - journals.sagepub.com
A prodrome is considered an early set of signs or symptoms indicating the onset of a
disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years …
disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years …
Embedding electronic health records onto a knowledge network recognizes prodromal features of multiple sclerosis and predicts diagnosis
Objective Early identification of chronic diseases is a pillar of precision medicine as it can
lead to improved outcomes, reduction of disease burden, and lower healthcare costs …
lead to improved outcomes, reduction of disease burden, and lower healthcare costs …
Revisiting the pathoetiology of multiple sclerosis: has the tail been wagging the mouse?
MK Sen, MSM Almuslehi, PJ Shortland… - Frontiers in …, 2020 - frontiersin.org
Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …
disease, the pathoetiology of which is unknown. However, the key question remains whether …
Differential impact of environmental factors on systemic and localized autoimmunity
The influence of environmental factors on the development of autoimmune disease is being
broadly investigated to better understand the multifactorial nature of autoimmune …
broadly investigated to better understand the multifactorial nature of autoimmune …