Metabolic engineering of plant oils and waxes for use as industrial feedstocks

T Vanhercke, CC Wood, S Stymne… - Plant biotechnology …, 2013 - Wiley Online Library
Society has come to rely heavily on mineral oil for both energy and petrochemical needs.
Plant lipids are uniquely suited to serve as a renewable source of high‐value fatty acids for …

Filamentous fungi for production of food additives and processing aids

DB Archer, IF Connerton, DA MacKenzie - Food Biotechnology, 2008 - Springer
Filamentous fungi are metabolically versatile organisms with a very wide distribution in
nature. They exist in association with other species, eg as lichens or mycorrhiza, as …

Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development

Ö Bayram, K Feussner, M Dumkow, C Herrfurth… - Fungal Genetics and …, 2016 - Elsevier
Fungal development and secondary metabolite production are coordinated by regulatory
complexes as the trimeric velvet complex. Light accelerates asexual but decreases sexual …

Comprehensive analysis of the composition of the major phospholipids during the asexual life cycle of the filamentous fungus Aspergillus nidulans

R Iwama, N Okahashi, T Suzawa, C Yang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Filamentous fungi undergo significant cellular morphological changes during their life cycle.
It has recently been reported that deletions of genes that are involved in phospholipid …

Caenorhabditis elegans Δ12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Δ12 and Δ15 positions

XR Zhou, AG Green, SP Singh - Journal of Biological Chemistry, 2011 - ASBMB
Caenorhabditis elegans FAT-2 has been characterized as fatty acid Δ12-desaturase able to
desaturate C16 and C18 fatty acids. However, in this report we show that when expressed in …

Identification of PpoA from Aspergillus nidulans as a Fusion Protein of a Fatty Acid Heme Dioxygenase/Peroxidase and a Cytochrome P450*♦

F Brodhun, C Gobel, E Hornung, I Feussner - Journal of Biological …, 2009 - ASBMB
The homothallic ascomycete Aspergillus nidulans serves as model organism for filamentous
fungi because of its ability to propagate with both asexual and sexual life cycles, and fatty …

Increase of eicosapentaenoic acid in thraustochytrids through thraustochytrid ubiquitin promoter-driven expression of a fatty acid Δ5 desaturase gene

T Kobayashi, K Sakaguchi, T Matsuda… - Applied and …, 2011 - Am Soc Microbiol
Thraustochytrids, marine protists known to accumulate polyunsaturated fatty acids (PUFAs)
in lipid droplets, are considered an alternative to fish oils as a source of PUFAs. The major …

Molecular mechanism of substrate specificity for delta 6 desaturase from Mortierella alpina and Micromonas pusilla

H Shi, H Chen, Z Gu, Y Song, H Zhang, W Chen… - Journal of Lipid …, 2015 - ASBMB
The ω6 and ω3 pathways are two major pathways in the biosynthesis of PUFAs. In both of
these, delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or …

Molecular Evolution and Functional Diversification of Fatty Acid Desaturases after Recurrent Gene Duplication in Drosophila

S Fang, CT Ting, CR Lee, KH Chu… - Molecular biology …, 2009 - academic.oup.com
Frequent gene duplications in the genome incessantly supply new genetic materials for
functional innovation presumably driven by positive Darwinian selection. This mechanism in …

ω3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use

M Wang, H Chen, Z Gu, H Zhang, W Chen… - Applied microbiology and …, 2013 - Springer
The biosynthesis of very-long-chain polyunsaturated fatty acids involves an alternating
process of fatty acid desaturation and elongation catalyzed by complex series of enzymes …