Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …
increase comes exponentially rising social and economic costs, emphasizing the immediate …
The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
Function of alternative splicing
O Kelemen, P Convertini, Z Zhang, Y Wen, M Shen… - Gene, 2013 - Elsevier
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …
the functions of alternative splicing events that have been experimentally determined. The …
Modulation of striatal projection systems by dopamine
CR Gerfen, DJ Surmeier - Annual review of neuroscience, 2011 - annualreviews.org
The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal
projection systems—so-called direct and indirect pathways—form the functional backbone of …
projection systems—so-called direct and indirect pathways—form the functional backbone of …
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
Dopamine shapes a wide variety of psychomotor functions. This is mainly accomplished by
modulating cortical and thalamic glutamatergic signals impinging upon principal medium …
modulating cortical and thalamic glutamatergic signals impinging upon principal medium …
[HTML][HTML] Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia
T Fieblinger, SM Graves, LE Sebel, C Alcacer… - Nature …, 2014 - nature.com
The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson's disease (PD)
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
'Rejuvenation'protects neurons in mouse models of Parkinson's disease
CS Chan, JN Guzman, E Ilijic, JN Mercer, C Rick… - Nature, 2007 - nature.com
Why dopamine-containing neurons of the brain's substantia nigra pars compacta die in
Parkinson's disease has been an enduring mystery. Our studies suggest that the unusual …
Parkinson's disease has been an enduring mystery. Our studies suggest that the unusual …
Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models
M Day, Z Wang, J Ding, X An, CA Ingham… - Nature …, 2006 - nature.com
Parkinson disease is a common neurodegenerative disorder that leads to difficulty in
effectively translating thought into action. Although it is known that dopaminergic neurons …
effectively translating thought into action. Although it is known that dopaminergic neurons …
Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
SM Baig, A Koschak, A Lieb, M Gebhart… - Nature …, 2011 - nature.com
Deafness is genetically very heterogeneous and forms part of several syndromes. So far,
delayed rectifier potassium channels have been linked to human deafness associated with …
delayed rectifier potassium channels have been linked to human deafness associated with …
L‐type Ca2+ channels in heart and brain
J Striessnig, A Pinggera, G Kaur… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …