Accumulating evidence suggests that insults occurring during the perinatal period alter the
developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …

BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting reproductive-aged women. The pathophysiology of this syndrome is still not …

The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to
provide the historical context to current research, and most importantly as an aid for …

Polycystic ovary syndrome (PCOS) is a fertility disorder affecting 5–7% of reproductive-aged
women. Women with PCOS manifest both reproductive and metabolic defects. Several …

The prenatal testosterone (T)-treated adult female rhesus monkey is one animal model of
polycystic ovary syndrome (PCOS) in women, with early prenatal T excess programming a …

Background: Conditions of excess androgen in women, such as polycystic ovary syndrome
(PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS …

Estrogen exerts a critical regulatory influence upon the biosynthetic and secretory activity of
the gonadotropin-releasing hormone (GnRH) neurons. It seems likely that estrogen …

BACKGROUND According to the Developmental Origins of Health and Disease (DOHaD)
hypothesis, environmental changes taking place during early maturational periods may alter …

Exposure to testosterone (T) during d 30–90 of fetal life results in low-birth-weight offspring,
hypergonadotropism, multifollicular ovaries, and early cessation of cyclicity. The …

Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of
reproductive age. The potential causes of androgen excess in women include polycystic …