Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

The autophagy-lysosome pathway plays a fundamental role in the clearance of aggregated
proteins and protection against cellular stress and neurodegenerative conditions. Alterations …

Hypertrophic cardiomyopathy (HCM) is a myocardial disease characterized by left
ventricular hypertrophy not solely explained by abnormal loading conditions. Despite its rare …

Beside inherited muscle diseases many catabolic conditions such as insulin resistance,
malnutrition, cancer growth, aging, infections, chronic inflammatory status, inactivity, obesity …

Danon disease is a severe multisystem disorder clinically characterized by hypertrophic
cardiomyopathy, skeletal myopathy and mental retardation in male patients, and by a milder …

Although advances in medical technology and health care have improved the early
diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity …

Restrictive cardiomyopathy (RCM) is a heterogeneous group of diseases characterized by
restrictive left ventricular pathophysiology, ie a rapid rise in ventricular pressure with only …

Autophagy is a very well-coordinated intracellular process that maintains cellular
homeostasis under basal conditions by removing unnecessary or dysfunctional components …

The focus of this review is the development of gene therapy for glycogen storage diseases
(GSDs). GSD results from the deficiency of specific enzymes involved in the storage and …