The emergence of single‐cell RNA sequencing enables simultaneous sequencing of
thousands of cells, making the analysis of cell population heterogeneity more efficient. In …

Background Quality control (QC) of cells, a critical first step in single-cell RNA sequencing
data analysis, has largely relied on arbitrarily fixed data-agnostic thresholds applied to QC …

Background Chronic alcohol consumption and alcohol use disorder have a tremendous
impact on the patient's psychological and physiological health. There is evidence that …

Background: Acting as a viral entry for coronavirus to invade human cells, TMPRSS2 has
become a target for the prevention and treatment of COVID-19 infection. Before this …

Introduction Resveratrol, an activator for longevity regulatory genes-sirtuin family (SIRTs)
and Sirtuin 2 (SIRT2) is an important factor of SIRTs which demonstrated biological function …

Micropillars have emerged as promising tools for a wide range of biological applications,
while the influence of magnetic fields on cell behavior regulation has been increasingly …

Hepatocellular carcinoma (HCC) is a typical highly heterogeneous solid tumor with high
morbidity and mortality worldwide, especially in China; however, the immune …

随着单细胞RNA 测序技术的发展, 目前单细胞测序通量由上千细胞发展到主流上万细胞的规模.
基于单细胞RNA 测序数据的细胞分型是研究细胞的重要问题之一, 该问题主要运用无监督聚类 …

To date, there are only limited pharmacological treatments to cure AUD and the success rate
is very low. Therefore, new therapeutic routes are warranted. This thesis aims to contribute …