The MYC family oncogene is deregulated in> 50% of human cancers, and this deregulation
is frequently associated with poor prognosis and unfavorable patient survival. Myc has a …

The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin
(mTOR) signaling pathways are two pathways crucial to many aspects of cell growth and …

The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

Aberrations in various cellular signaling pathways are instrumental in regulating cellular
metabolism, tumor development, growth, proliferation, metastasis and cytoskeletal …

Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine
protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and …

The phosphatidylinositol‐3 kinase (PI3K)–AKT pathway is one of the most commonly
dysregulated pathways in all of cancer, with somatic mutations, copy number alterations …

PTEN is among the most frequently inactivated tumour suppressor genes in sporadic
cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Covering: up to March 2013 In addition to their prominent role in basic biological and
chemical research, natural products are a rich source of commercial products for the …