The role of human milk lipids and lipid metabolites in protecting the infant against non-communicable disease

AD George, S Burugupalli, S Paul, T Mansell… - International Journal of …, 2022 - mdpi.com
Non-communicable diseases continue to increase globally and have their origins early in
life. Early life obesity tracks from childhood to adulthood, is associated with obesity …

Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

C Géhin, SJ Fowler, DK Trivedi - Analytical Science Advances, 2023 - Wiley Online Library
Lipids are biological molecules that play vital roles in all living organisms. They perform
many cellular functions, such as 1) forming cellular and subcellular membranes, 2) storing …

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse …

C Symeonides, K Vacy, S Thomson, S Tanner… - Nature …, 2024 - nature.com
Male sex, early life chemical exposure and the brain aromatase enzyme have been
implicated in autism spectrum disorder (ASD). In the Barwon Infant Study birth cohort (n …

Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study

SA Mir, L Chen, S Burugupalli, B Burla, S Ji, AAT Smith… - BMC medicine, 2022 - Springer
Background Lipids play a vital role in health and disease, but changes to their circulating
levels and the link with obesity remain poorly characterized in expecting mothers and their …

Cord blood lipid correlation network profiles are associated with subsequent attention-deficit/hyperactivity disorder and autism spectrum disorder symptoms at 2 years …

K Vacy, S Thomson, A Moore, A Eisner, S Tanner… - …, 2024 - thelancet.com
Background Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder
(ASD) are neurodevelopmental conditions with early life origins. Alterations in blood lipids …

Early life stress detection using physiological signals and machine learning pipelines

Z Shahbazi, YC Byun - Biology, 2023 - mdpi.com
Simple Summary Problem statement: Stress is one of the challenges of human life that in
case of not curing may cause serious problems in human body. There are various type of …

Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study

T Mansell, R Saffery, S Burugupalli, AL Ponsonby… - Elife, 2022 - elifesciences.org
Background: The risk of adult onset cardiovascular and metabolic (cardiometabolic) disease
accrues from early life. Infection is ubiquitous in infancy and induces inflammation, a key …

Next generation, modifiable cardiometabolic biomarkers: mitochondrial adaptation and metabolic resilience: a scientific statement from the American Heart …

M Mietus-Snyder, AM Perak, S Cheng, LL Hayman… - Circulation, 2023 - Am Heart Assoc
Cardiometabolic risk is increasing in prevalence across the life span with disproportionate
ramifications for youth at socioeconomic disadvantage. Established risk factors and …

Defining the lipid profiles of human milk, infant formula, and animal milk: implications for infant feeding

AD George, S Paul, T Wang, K Huynh, C Giles… - Frontiers in …, 2023 - frontiersin.org
Background Breastfed infants have lower disease risk compared to formula-fed infants,
however, the mechanisms behind this protection are unknown. Human milk has a complex …

Alkylglycerol: not abundant but promising functional lipid

HL Wang, CP Tan, Y Liu, YJ Xu - Trends in Food Science & Technology, 2024 - Elsevier
Background Alkylglycerols are a special class of functional ether lipids. In recent years,
these functional lipids have garnered significant attention due to their unique biological …