Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

The triazolopyrimidine scaffold represents one of the privileged structure in chemistry, and
there has been an increase in number of studies utilizing this scaffold and its derivatives …

Background Neglected parasitic diseases (NTDs) like cutaneous leishmaniasis (CL) have
caused high mortality and morbidity rate in developing countries. This disease is considered …

Leishmaniasis is a group of infectious-parasitic diseases with high mortality rates, and
endemic in many regions of the globe. The currently available drugs present serious …

Six novel nickel (II) complexes with the non-steroidal anti-inflammatory drug mefenamic acid
(Hmef) with the nitrogen-donor heterocyclic ligands 2, 2′-bipyridine (bipy), 2, 2 …

Leishmaniasis is a neglected disease caused by protozoa belonging to the Leishmania
genus. Notably, the search for new, promising and potent anti-Leishmania compounds …

Nanoemulsions are drug delivery systems that may increase the penetration of lipophilic
compounds through the skin, enhancing their topical effect. Chalcones are compounds of …

A variety of structurally different pyrimidines were synthesized. Elemental analysis, FT-IR, 1H
NMR, and 13C NMR spectroscopy were used to confirm the chemical structures of all …

Herein, we report the synthesis, characterization and anticancer activity of six novel
complexes of non-steroidal anti-inflammatory drug niflumic acid with Co (II) and Ni (II). In …

Leishmaniasis and Chagas disease remain a significant global problem. Current treatments
have serious disadvantage due to cost, toxicity, long therapy duration and resistance. In the …