Vascular endothelial growth factor: therapeutic possibilities and challenges for the treatment of ischemia

TD Crafts, AR Jensen, EC Blocher-Smith, TA Markel - Cytokine, 2015 - Elsevier
Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in
angiogenesis and vasculogenesis. The contemporary body of literature contains a …

[HTML][HTML] Angiotensin II type 1 receptor antagonists in animal models of vascular, cardiac, metabolic and renal disease

MC Michel, HR Brunner, C Foster, Y Huo - Pharmacology & therapeutics, 2016 - Elsevier
We have reviewed the effects of angiotensin II type 1 receptor antagonists (ARBs) in various
animal models of hypertension, atherosclerosis, cardiac function, hypertrophy and fibrosis …

Telmisartan attenuates diabetic nephropathy by mitigating oxidative stress and inflammation, and upregulating Nrf2/HO-1 signaling in diabetic rats

SA Antar, W Abdo, RS Taha, AE Farage, LE El-Moselhy… - Life sciences, 2022 - Elsevier
Diabetic nephropathy (DN) is a serious complication of diabetes and can lead to renal
failure. Telmisartan (TEL) is an approved angiotensin II type 1 receptor blocker for the …

Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment

J Liu, W Hou, T Guan, L Tang, X Zhu, Y Li, S Hou… - Angiogenesis, 2018 - Springer
Abnormal angiogenesis plays a pathological role in diabetic nephropathy (DN), contributing
to glomerular hypertrophy and microalbuminuria. Slit2/Robo1 signaling participates in …

Effects of telmisartan on vascular endothelial function, inflammation and insulin resistance in patients with coronary heart disease and diabetes mellitus

T Chen, J Xing, Y Liu - Experimental and Therapeutic …, 2018 - spandidos-publications.com
The aim of the present study was to investigate the effects of telmisartan on vascular
endothelial functions, inflammatory factors and insulin resistance of coronary heart disease …

Combination of telmisartan with sildenafil ameliorate progression of diabetic nephropathy in streptozotocin-induced diabetic model

NA El-Mahdy, MES El-Sayad, AH El-Kadem - Biomedicine & …, 2016 - Elsevier
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in the world.
Several signaling pathways are involved in the pathogenesis of DN including elevation in …

Telmisartan loaded polycaprolactone/gelatin-based electrospun vascular scaffolds

M Birer, F Acartürk - … Journal of Polymeric Materials and Polymeric …, 2022 - Taylor & Francis
Small diameter vascular grafts are frequently used in the treatment of cardiovascular
diseases. The aim of this study is to design electrospun telmisartan (TEL)-loaded …

A protective role of Gαq-RGS2 loop activator on streptozotocin induced diabetic complications in rats: an independent on elevated serum glucose level modulation

JV Beladiya, KK Chaudagar, AA Mehta - European Journal of …, 2018 - Elsevier
An overactivation of Gαq dependent signaling pathway is crucial for development of
metabolic and vascular abnormalities in diabetes. Therefore, our objective was to study …

[PDF][PDF] 益气活血生肌方对难愈性创面愈合及血管再生的影响

骆渊城, 朱滨, 杨威, 王奎 - 中国医药导报 - yiyaodaobao.com.cn
目的探讨益气活血生肌方对糖尿病大鼠溃疡创面愈合及血管冉生的影响, 方法按照随机数字表法
将60 只SPF 级体重2810320 g, 8210 周龄的雄性SD 大鼠分成给药组, 难愈性创面组 …

VEGF-VEGFR2 信号轴对糖尿病血管生成反应的调控研究进展.

吴文, 张代民, 陈绍良, 左广锋… - Progress in Modern …, 2016 - search.ebscohost.com
血管内皮生长因子(Vacular endothelial growth factor, VEGF)-血管内皮生长因子受体-2 (VEGF
receptor 2, VEGF R-2) 信号轴调控血管生成反应. 糖尿病病理状态下, 氧化应激异常激活, NO …