Deleterious mutations continuously accumulate in populations, building up a burden that
can threaten their survival, particularly in small populations when inbreeding exposes …

Populations are introduced into novel environments in different contexts, one being the
biological control of pests. Despite intense efforts, less than half introduced biological control …

Using computer simulations, we evaluate the effects of genetic purging of inbreeding load in
small populations, assuming genetic models of deleterious mutations which account for the …

The role of epistasis in understanding the genetic architecture and variation of quantitative
traits and its role, if any, in artificial selection and livestock improvement more generally has …

The joint consequences of inbreeding, natural selection, and deleterious mutation on mean
fitness after population shrinkage are of great importance in evolution and can be critical to …

Here, López-Cortegano and Caballero carried out a meta-analysis using records from a
database of genome-wide studies in order to investigate the nature of missing heritability in …

Models of genetic effects integrate the action of genes, regulatory regions and interactions
among alleles across the genome. Such theoretical frameworks are critical for applied …

Epistasis may have important consequences for a number of issues in quantitative genetics
and evolutionary biology. In particular, synergistic epistasis for deleterious alleles is relevant …

Using computer simulation we explore the consequences of linkage on the inbreeding load
of an equilibrium population, and on the efficiency of purging and the loss of genetic …

The consequences of inbreeding for fitness are important in evolutionary and conservation
biology, but can critically depend on genetic purging. However, estimating purging has …