Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration.
Dysregulation of the Hippo pathway has been recognized in a variety of human cancers …

Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

Pseudolaric acid B (PAB), a natural product isolated from the root bark of Pseudolarix
kaempferi, has been reported to exert inhibitory effects in various cancers. However, the …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer.
Despite major advances in defining the molecular mutations driving PDAC, this disease …

Abstract Mammalian STE20-like kinase 1 (Mst1) is well recognized as a major tumor
suppressor in cancer development, growth, metabolic reprogramming, metastasis, cell death …

Background Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor of
the digestive system. Studies have shown that pseudolaric acid B (PAB) has several …

Yao S, Yan W. Onco Targets Ther. 2018; 11: 8465–8479. We, the Editors and Publisher of
OncoTargets and Therapy, have retracted the following article. Following publication of the …

The Hippo pathway is a key regulator of tissue growth, organ size, and tumorigenesis.
Activating the Hippo pathway by gene editing or pharmaceutical intervention has been …

Abstract Pseudolaric Acid B (PAB), a natural product with remarkable anti-tumor activity, is a
starting point for new anticancer therapeutics. We designed and synthesized 27 PAB …

Background. Liver cancer, particularly hepatocellular carcinoma (HCC), is the fourth leading
cause of cancer‐related death worldwide. Sorafenib is a crucial drug for the treatment of …