Fundamental Aspects of Phase-Separated Biomolecular Condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
Biomolecular condensates in contact with membranes
A Mangiarotti, R Dimova - Annual Review of Biophysics, 2024 - annualreviews.org
Biomolecular condensates are highly versatile membraneless organelles involved in a
plethora of cellular processes. Recent years have witnessed growing evidence of the …
plethora of cellular processes. Recent years have witnessed growing evidence of the …
Liquid spherical shells are a non-equilibrium steady state of active droplets
AM Bergmann, J Bauermann, G Bartolucci… - Nature …, 2023 - nature.com
Liquid-liquid phase separation yields spherical droplets that eventually coarsen to one
large, stable droplet governed by the principle of minimal free energy. In chemically fueled …
large, stable droplet governed by the principle of minimal free energy. In chemically fueled …
Thermodynamic forces from protein and water govern condensate formation of an intrinsically disordered protein domain
S Mukherjee, LV Schäfer - Nature Communications, 2023 - nature.com
Liquid-liquid phase separation (LLPS) can drive a multitude of cellular processes by
compartmentalizing biological cells via the formation of dense liquid biomolecular …
compartmentalizing biological cells via the formation of dense liquid biomolecular …
Multiphasic coacervates assembled by hydrogen bonding and hydrophobic interactions
Coacervation has emerged as a prevalent mechanism to compartmentalize biomolecules in
living cells. Synthetic coacervates help in understanding the assembly process and mimic …
living cells. Synthetic coacervates help in understanding the assembly process and mimic …
Biomolecular condensates modulate membrane lipid packing and hydration
Membrane wetting by biomolecular condensates recently emerged as a key phenomenon in
cell biology, playing an important role in a diverse range of processes across different …
cell biology, playing an important role in a diverse range of processes across different …
Visualizing formation and dynamics of a three-dimensional sponge-like network of a coacervate in real time
R Kubota, T Hiroi, Y Ikuta, Y Liu… - Journal of the American …, 2023 - ACS Publications
Coacervates, which are formed by liquid–liquid phase separation, have been extensively
explored as models for synthetic cells and membraneless organelles, so their in-depth …
explored as models for synthetic cells and membraneless organelles, so their in-depth …
Dominance analysis to assess solute contributions to multicomponent phase equilibria
Phase separation in aqueous solutions of macromolecules underlies the generation of
biomolecular condensates in cells. Condensates are membraneless bodies, representing …
biomolecular condensates in cells. Condensates are membraneless bodies, representing …
Femtoliter oil droplets act as CO2 micropumps for uninterrupted electrochemiluminescence at the water| oil interface
Interfacial effects are well-known to significantly alter chemical reactivity, especially in
confined environments, where the surface to volume ratio increases. Here, we observed an …
confined environments, where the surface to volume ratio increases. Here, we observed an …
Protein Compartments Modulate Fibrillar Self‐Assembly
S Karger, ME Miali, A Solomonov, D Eliaz, N Varsano… - Small, 2024 - Wiley Online Library
A notable feature of complex cellular environments is protein‐rich compartments that are
formed via liquid–liquid phase separation. Recent studies have shown that these …
formed via liquid–liquid phase separation. Recent studies have shown that these …