Sporozoite immunization: innovative translational science to support the fight against malaria
TL Richie, LWP Church, T Murshedkar… - Expert review of …, 2023 - Taylor & Francis
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …
Cell biology and immunology of malaria
JC Hafalla, O Silvie, K Matuschewski - Immunological reviews, 2011 - Wiley Online Library
Malaria is a vector‐borne infectious disease caused by unicellular parasites of the genus
Plasmodium. These obligate intracellular parasites have the unique capacity to infect and …
Plasmodium. These obligate intracellular parasites have the unique capacity to infect and …
An Intensive Longitudinal Cohort Study of Malian Children and Adults Reveals No Evidence of Acquired Immunity to Plasmodium falciparum Infection
Background In experimental models of human and mouse malaria, sterilizing liver stage
immunity that blocks progression of Plasmodium infection to the symptomatic blood stage …
immunity that blocks progression of Plasmodium infection to the symptomatic blood stage …
Impact of sickle cell trait and naturally acquired immunity on uncomplicated malaria after controlled human malaria infection in adults in Gabon
Controlled human malaria infection (CHMI) by direct venous inoculation (DVI) with 3,200
cryopreserved Plasmodium falciparum sporozoites (PfSPZ) consistently leads to parasitemia …
cryopreserved Plasmodium falciparum sporozoites (PfSPZ) consistently leads to parasitemia …
Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections
P Liehl, P Meireles, IS Albuquerque… - Infection and …, 2015 - Am Soc Microbiol
Following transmission through a mosquito bite to the mammalian host, Plasmodium
parasites first invade and replicate inside hepatocytes before infecting erythrocytes and …
parasites first invade and replicate inside hepatocytes before infecting erythrocytes and …
Naturally acquired immune responses against Plasmodium falciparum sporozoites and liver infection
Malaria is a vector-borne infectious disease caused by infection with eukaryotic pathogens
termed Plasmodium. Epidemiological hallmarks of Plasmodium falciparum malaria are …
termed Plasmodium. Epidemiological hallmarks of Plasmodium falciparum malaria are …
Association of antibodies to Plasmodium falciparum merozoite surface protein-4 with protection against clinical malaria
R Perraut, ML Varela, C Joos, B Diouf, C Sokhna… - Vaccine, 2017 - Elsevier
Identification of parasite antigens targeted by immune effector mechanisms that confer
protection against malaria is important for the design of a multi-component malaria vaccine …
protection against malaria is important for the design of a multi-component malaria vaccine …
Decreased Growth Rate of P. falciparum Blood Stage Parasitemia With Age in a Holoendemic Population
M Pinkevych, J Petravic, K Chelimo… - The Journal of …, 2014 - academic.oup.com
In malaria holoendemic settings, decreased parasitemia and clinical disease is associated
with age and cumulative exposure. The relative contribution of acquired immunity against …
with age and cumulative exposure. The relative contribution of acquired immunity against …
Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria
H Ganeshan, KA Kusi, D Anum, MR Hollingdale… - Malaria Journal, 2016 - Springer
Background Malaria eradication requires a concerted approach involving all available
control tools, and an effective vaccine would complement these efforts. An effective malaria …
control tools, and an effective vaccine would complement these efforts. An effective malaria …
High sporozoite antibody titers in conjunction with microscopically detectable blood infection display signatures of protection from clinical malaria
Immunoepidemiological studies typically reveal slow, age-dependent acquisition of immune
responses against Plasmodium falciparum sporozoites. Naturally acquired immunity against …
responses against Plasmodium falciparum sporozoites. Naturally acquired immunity against …