The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Eicosanoids represent a diverse family of lipid mediators with fundamental roles in
physiology and disease. Within the eicosanoid superfamily are prostanoids, which are …

The primary cilium is a signaling compartment that interprets Hedgehog signals through
changes of its protein, lipid, and second messenger compositions. Here, we combine …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Neural circuit assembly in the brain requires precise establishment of synaptic connections,
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …

How cAMP generates hormone-specific effects has been debated for many decades.
Fluorescence resonance energy transfer (FRET)-based sensors for cAMP allow real-time …

To cope with sudden changes in the external environment, the budding yeast
Saccharomyces cerevisiae orchestrates a multifaceted response that spans many levels of …

The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and
regeneration. Dysfunction of this cascade drives several cancers. To control expression of …

cAMP-dependent pathway is one of the most significant signaling cascades in healthy and
neoplastic ovarian cells. Working through its major effector proteins—PKA and EPAC—it …

The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular
function, including cellular metabolism, division, proliferation, transcription, movement, and …