PANTHER: Making genome‐scale phylogenetics accessible to all
PD Thomas, D Ebert, A Muruganujan… - Protein …, 2022 - Wiley Online Library
Phylogenetics is a powerful tool for analyzing protein sequences, by inferring their
evolutionary relationships to other proteins. However, phylogenetics analyses can be …
evolutionary relationships to other proteins. However, phylogenetics analyses can be …
Reexamining assumptions about miRNA-guided gene silencing
MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …
regulate the expression of any RNA. This potential has led to the publication of several …
Enrichr-KG: bridging enrichment analysis across multiple libraries
Gene and protein set enrichment analysis is a critical step in the analysis of data collected
from omics experiments. Enrichr is a popular gene set enrichment analysis web-server …
from omics experiments. Enrichr is a popular gene set enrichment analysis web-server …
Genome interpretation using in silico predictors of variant impact
Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …
personalized therapeutic opportunities. Clinical associations and laboratory experiments …
Nobel Turing Challenge: creating the engine for scientific discovery
H Kitano - NPJ systems biology and applications, 2021 - nature.com
Scientific discovery has long been one of the central driving forces in our civilization. It
uncovered the principles of the world we live in, and enabled us to invent new technologies …
uncovered the principles of the world we live in, and enabled us to invent new technologies …
Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung …
K Yang, W Zhang, L Zhong, Y Xiao, S Sahoo… - Cell Death & …, 2023 - nature.com
Lung cancer is the leading cause of cancer-related deaths worldwide. KRAS is the main
oncogenic driver in lung cancer that can be activated by gene mutation or amplification, but …
oncogenic driver in lung cancer that can be activated by gene mutation or amplification, but …
Co-factors, microbes, and immunogenetics in celiac disease to guide novel approaches for diagnosis and treatment
EF Verdu, D Schuppan - Gastroenterology, 2021 - Elsevier
Celiac disease (CeD) is a frequent immune-mediated disease that affects not only the small
intestine but also many extraintestinal sites. The role of gluten proteins as dietary triggers …
intestine but also many extraintestinal sites. The role of gluten proteins as dietary triggers …
Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects
Prostate cancer (PrCa) is the second most common cancer worldwide in males. While
strongly warranted, the prediction of mortality risk due to PrCa, especially before its …
strongly warranted, the prediction of mortality risk due to PrCa, especially before its …
Drug target prediction through deep learning functional representation of gene signatures
Many machine learning applications in bioinformatics currently rely on matching gene
identities when analyzing input gene signatures and fail to take advantage of preexisting …
identities when analyzing input gene signatures and fail to take advantage of preexisting …