One of the earliest cellular responses to DNA double strand breaks (DSBs) is the
phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the …

Simple Summary The increase of exposure to ionizing radiation (IR) from medical
procedures has prompted research into improving methodologies for the detection of DNA …

Accurate and reproducible quantification of the accumulation of proteins into foci in cells is
essential for data interpretation and for biological inferences. To improve reproducibility …

DNA double-strand breaks (DSBs) and blocked replication forks resulting from bulky
adducts and inhibitors of replication activate the DNA damage response (DDR), a signaling …

Accumulation of 8-OHdG damage in DNA may result in various pathologies, including
neurodegeneration and cancer. The significantly altered level of base damage analyzed by …

Antibody assessment is an essential part in the serological diagnosis of autoimmune
diseases. However, different diagnostic strategies have been proposed for the work up of …

Robust predictive models are essential to manage the risk of radiation-induced
carcinogenesis. Chronic exposure to cosmic rays in the context of the complex deep space …

The global use of magnetic resonance imaging (MRI) is constantly growing and the field
strengths increasing. Yet, only little data about harmful biological effects caused by MRI …

Abstract Analysis of phosphorylated histone protein H2AX (γH2AX) foci is currently the most
sensitive method to detect DNA double‐strand breaks (DSB). This protein modification has …

Double-strand breaks (DSBs) are the most lethal DNA damages induced by ionising
radiation (IR) and their efficient repair is crucial to limit genomic instability. The cellular DSB …