Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

The ongoing obesity pandemic generates a constant need to develop new therapeutic
strategies to restore the energy balance. Therefore, the concept of activating brown adipose …

Obesity-associated metabolic abnormalities comprise a cluster of conditions including
dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected …

Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it
secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As …

Throughout the 20th and 21st centuries, the incidence of non-communicable diseases
(NCDs), also known as chronic diseases, has been increasing worldwide. Changes in …

The prevalence of “diabesity”–diabetes related to obesity–has increased tremendously over
the past few decades because of the global obesity epidemic. Although bariatric surgery is …

Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food
intake triggered steep increase in the incidence of metabolic disorders including obesity and …

Brown adipose tissue (BAT) is proposed to maintain thermal homeostasis through
dissipation of chemical energy as heat by the uncoupling proteins (UCPs) present in their …

Excessive accumulation of white adipose tissue leads to obesity and its associated
metabolic health consequences such as type 2 diabetes and cardiovascular disease …