Using clusterProfiler to characterize multiomics data

S Xu, E Hu, Y Cai, Z Xie, X Luo, L Zhan, W Tang… - Nature protocols, 2024 - nature.com
With the advent of multiomics, software capable of multidimensional enrichment analysis
has become increasingly crucial for uncovering gene set variations in biological processes …

Analysis of microbial compositions: a review of normalization and differential abundance analysis

H Lin, SD Peddada - NPJ biofilms and microbiomes, 2020 - nature.com
Increasingly, researchers are discovering associations between microbiome and a wide
range of human diseases such as obesity, inflammatory bowel diseases, HIV, and so on …

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

EN Baruch, I Youngster, G Ben-Betzalel, R Ortenberg… - Science, 2021 - science.org
The gut microbiome has been shown to influence the response of tumors to anti–PD-1
(programmed cell death–1) immunotherapy in preclinical mouse models and observational …

A new genomic blueprint of the human gut microbiota

A Almeida, AL Mitchell, M Boland, SC Forster, GB Gloor… - Nature, 2019 - nature.com
The composition of the human gut microbiota is linked to health and disease, but knowledge
of individual microbial species is needed to decipher their biological roles. Despite …

[HTML][HTML] A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

DJ Ahern, Z Ai, M Ainsworth, C Allan, A Allcock… - Cell, 2022 - cell.com
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …

Caloric restriction disrupts the microbiota and colonization resistance

RJ von Schwartzenberg, JE Bisanz, S Lyalina… - Nature, 2021 - nature.com
Diet is a major factor that shapes the gut microbiome, but the consequences of diet-induced
changes in the microbiome for host pathophysiology remain poorly understood. We …

Microbiome datasets are compositional: and this is not optional

GB Gloor, JM Macklaim, V Pawlowsky-Glahn… - Frontiers in …, 2017 - frontiersin.org
Datasets collected by high-throughput sequencing (HTS) of 16S rRNA gene amplimers,
metagenomes or metatranscriptomes are commonplace and being used to study human …

From hairballs to hypotheses–biological insights from microbial networks

L Röttjers, K Faust - FEMS microbiology reviews, 2018 - academic.oup.com
Microbial networks are an increasingly popular tool to investigate microbial community
structure, as they integrate multiple types of information and may represent systems-level …

Allogenic fecal microbiota transplantation in patients with nonalcoholic fatty liver disease improves abnormal small intestinal permeability: a randomized control trial

L Craven, A Rahman, SN Parvathy… - Official journal of the …, 2020 - journals.lww.com
METHODS: Twenty-one patients with NAFLD were recruited and randomized in a ratio of 3:
1 to either an allogenic (n= 15) or an autologous (n= 6) FMT delivered by using an …

ggpicrust2: an R package for PICRUSt2 predicted functional profile analysis and visualization

C Yang, J Mai, X Cao, A Burberry, F Cominelli… - …, 2023 - academic.oup.com
Microbiome research is now moving beyond the compositional analysis of microbial taxa in
a sample. Increasing evidence from large human microbiome studies suggests that …