miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

Fibrosis in chronic kidney disease: pathogenesis and consequences

S Panizo, L Martínez-Arias, C Alonso-Montes… - International journal of …, 2021 - mdpi.com
Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The …

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

S Zhou, J Jin, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
world. Although considerable progress has been made in the diagnosis, treatment and …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

MicroRNA regulation of atherosclerosis

MW Feinberg, KJ Moore - Circulation research, 2016 - Am Heart Assoc
Atherosclerosis and its attendant clinical complications, such as myocardial infarction,
stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in …

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

W Poller, S Dimmeler, S Heymans, T Zeller… - European heart …, 2018 - academic.oup.com
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

MicroRNAs in cardiovascular disease

T Barwari, A Joshi, M Mayr - Journal of the American College of Cardiology, 2016 - jacc.org
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …

Circulating noncoding RNAs as biomarkers of cardiovascular disease and injury

J Viereck, T Thum - Circulation research, 2017 - Am Heart Assoc
The discovery of thousands of noncoding RNAs (ncRNAs) has expanded our view on
mammalian genomes and transcriptomes, as well as their organization and regulation …

Extracellular vesicles in cardiovascular disease: biological functions and therapeutic implications

C Han, J Yang, J Sun, G Qin - Pharmacology & therapeutics, 2022 - Elsevier
Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer
particles naturally released from the cell. While exosomes are formed as intraluminal …

Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review

R Navickas, D Gal, A Laucevičius… - Cardiovascular …, 2016 - academic.oup.com
The aim of the present study is to identify microRNAs (miRs) with high potential to be used
as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis …