Ten challenges for clinical translation in psychiatric genetics

EM Derks, JG Thorp, ZF Gerring - Nature Genetics, 2022 - nature.com
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

The genetic landscape of substance use disorders

ZF Gerring, JG Thorp, JL Treur, KJH Verweij… - Molecular …, 2024 - nature.com
Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …

Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases

RH Reynolds, AZ Wagen, F Lona-Durazo… - npj Parkinson's …, 2023 - nature.com
Genetic correlation (rg) between traits can offer valuable insight into underlying shared
biological mechanisms. Neurodegenerative diseases overlap neuropathologically and often …

Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders

M Tesfaye, P Jaholkowski, AA Shadrin… - Psychiatry and …, 2024 - Wiley Online Library
Aims Anxiety disorders are prevalent and anxiety symptoms (ANX) co‐occur with many
psychiatric disorders. We aimed to identify genomic loci associated with ANX, characterize …

[HTML][HTML] Investigating genetic overlap between Alzheimer's disease, lipids, and coronary artery disease: A large-scale genome-wide cross trait analysis

A Kirby, T Porter, EO Adewuyi, SM Laws - International Journal of …, 2024 - mdpi.com
There is evidence to support a link between abnormal lipid metabolism and Alzheimer's
disease (AD) risk. Similarly, observational studies suggest a comorbid relationship between …

Correlation scan: identifying genomic regions that affect genetic correlations applied to fertility traits

BS Olasege, LR Porto-Neto, MS Tahir, GC Gouveia… - BMC genomics, 2022 - Springer
Although the genetic correlations between complex traits have been estimated for more than
a century, only recently we have started to map and understand the precise localization of …

Improving multi-population genomic prediction accuracy using multi-trait GBLUP models which incorporate global or local genetic correlation information

J Teng, T Zhai, X Zhang, C Zhao, W Wang… - Briefings in …, 2024 - academic.oup.com
In the application of genomic prediction, a situation often faced is that there are multiple
populations in which genomic prediction (GP) need to be conducted. A common way to …

xWAS analysis in neuropsychiatric disorders by integrating multi-molecular phenotype quantitative trait loci and GWAS summary data

L Luo, T Pang, H Zheng, C Liufu, S Chang - Journal of Translational …, 2024 - Springer
Background Integrating quantitative trait loci (QTL) data related to molecular phenotypes
with genome-wide association study (GWAS) data is an important post-GWAS strategic …

Dissecting loci that underpin the genetic correlations between production, fertility, and urea traits in Australian Holstein cattle

BS Olasege, I van den Berg, M Haile‐Mariam… - Animal …, 2024 - Wiley Online Library
Unfavorable genetic correlations between milk production, fertility, and urea traits have been
reported. However, knowledge of the genomic regions associated with these unfavorable …

Genomic regions and biological pathways associated with sex-limited reproductive traits in bovine species

BS Olasege, ZY Oh, MS Tahir… - Journal of Animal …, 2024 - academic.oup.com
Many animal species exhibit sex-limited traits, where certain phenotypes are exclusively
expressed in one sex. Yet, the genomic regions that contribute to these sex-limited traits in …