Ten challenges for clinical translation in psychiatric genetics
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …
underlying psychiatric disorders and provided important biological insights into disease …
The genetic landscape of substance use disorders
Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …
socioeconomic implications worldwide. Twin and family-based studies have long …
Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
RH Reynolds, AZ Wagen, F Lona-Durazo… - npj Parkinson's …, 2023 - nature.com
Genetic correlation (rg) between traits can offer valuable insight into underlying shared
biological mechanisms. Neurodegenerative diseases overlap neuropathologically and often …
biological mechanisms. Neurodegenerative diseases overlap neuropathologically and often …
Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders
M Tesfaye, P Jaholkowski, AA Shadrin… - Psychiatry and …, 2024 - Wiley Online Library
Aims Anxiety disorders are prevalent and anxiety symptoms (ANX) co‐occur with many
psychiatric disorders. We aimed to identify genomic loci associated with ANX, characterize …
psychiatric disorders. We aimed to identify genomic loci associated with ANX, characterize …
[HTML][HTML] Investigating genetic overlap between Alzheimer's disease, lipids, and coronary artery disease: A large-scale genome-wide cross trait analysis
There is evidence to support a link between abnormal lipid metabolism and Alzheimer's
disease (AD) risk. Similarly, observational studies suggest a comorbid relationship between …
disease (AD) risk. Similarly, observational studies suggest a comorbid relationship between …
Correlation scan: identifying genomic regions that affect genetic correlations applied to fertility traits
Although the genetic correlations between complex traits have been estimated for more than
a century, only recently we have started to map and understand the precise localization of …
a century, only recently we have started to map and understand the precise localization of …
Improving multi-population genomic prediction accuracy using multi-trait GBLUP models which incorporate global or local genetic correlation information
J Teng, T Zhai, X Zhang, C Zhao, W Wang… - Briefings in …, 2024 - academic.oup.com
In the application of genomic prediction, a situation often faced is that there are multiple
populations in which genomic prediction (GP) need to be conducted. A common way to …
populations in which genomic prediction (GP) need to be conducted. A common way to …
xWAS analysis in neuropsychiatric disorders by integrating multi-molecular phenotype quantitative trait loci and GWAS summary data
Background Integrating quantitative trait loci (QTL) data related to molecular phenotypes
with genome-wide association study (GWAS) data is an important post-GWAS strategic …
with genome-wide association study (GWAS) data is an important post-GWAS strategic …
Dissecting loci that underpin the genetic correlations between production, fertility, and urea traits in Australian Holstein cattle
Unfavorable genetic correlations between milk production, fertility, and urea traits have been
reported. However, knowledge of the genomic regions associated with these unfavorable …
reported. However, knowledge of the genomic regions associated with these unfavorable …
Genomic regions and biological pathways associated with sex-limited reproductive traits in bovine species
BS Olasege, ZY Oh, MS Tahir… - Journal of Animal …, 2024 - academic.oup.com
Many animal species exhibit sex-limited traits, where certain phenotypes are exclusively
expressed in one sex. Yet, the genomic regions that contribute to these sex-limited traits in …
expressed in one sex. Yet, the genomic regions that contribute to these sex-limited traits in …