Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …

Objective: We aimed to better understand the longitudinal course of low anterior resection
syndrome (LARS) to guide patient expectations and identify those at risk of persisting …

Patients with irritable bowel syndrome (IBS) have recurrent lower abdominal pain,
associated with altered bowel habit (diarrhea and/or constipation). As bowel habit is altered …

Background A total mesorectal excision for rectal cancer—although nerve‐and sphincter‐
sparing—can give rise to significant bowel symptoms, commonly referred to as low anterior …

Background The rectosigmoid brake, characterised by retrograde cyclic motor patterns on
high‐resolution colonic manometry, has been postulated as a contributor to the …

Motor function of the colon is essential for health. Our current understanding of the
mechanisms that underlie colonic motility are based upon a range of experimental …

The pathophysiology of fecal incontinence (FI) is often considered to primarily depend on
disturbed mechanisms of faecal containment. Barrier mechanisms such as the anal …

Purpose This study aims to identify the independent risk factors in the low anterior resection
syndrome (LARS) after surgery for colorectal cancer (CRC). Method This was a …

Abnormal cyclic motor pattern (CMP) activity is implicated in colonic dysfunction, but the only
tool to evaluate CMP activity, high-resolution colonic manometry (HRCM), remains …

Background & Aims The benefit of radiotherapy for rectal cancer is based largely on a
balance between a decrease in local recurrence and an increase in bowel dysfunction …