Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell …
H Azevedo-Barbosa, GÁ Ferreira-Silva, CF Silva… - Toxicology in Vitro, 2019 - Elsevier
Cancer is one of the most critical problems of public health in the world and one of the main
challenges for medicine. Different biological effects have been reported for sulfonamide …
challenges for medicine. Different biological effects have been reported for sulfonamide …
Two novel precursors of the hiv-1 protease inhibitor darunavir target the upr/proteasome system in human hepatocellular carcinoma cell line hepg2
R Rinaldi, R Miglionico, I Nigro, R D'Orsi… - Cells, 2021 - mdpi.com
Background: Several pre-clinical and clinical reports suggest that HIV-1 protease inhibitors,
in addition to the antiretroviral properties, possess pleiotropic pharmacological effects …
in addition to the antiretroviral properties, possess pleiotropic pharmacological effects …
New heteroaryl carbamates: Synthesis and biological screening in vitro and in mammalian cells of wild-type and mutant HIV-protease inhibitors
F Tramutola, MF Armentano, F Berti… - Bioorganic & Medicinal …, 2019 - Elsevier
New heteroaryl HIV-protease inhibitors bearing a carbamoyl spacer were synthesized in few
steps and high yield, from commercially available homochiral epoxides. Different …
steps and high yield, from commercially available homochiral epoxides. Different …
The Pseudo-Symmetric N-benzyl Hydroxyethylamine Core in a New Series of Heteroarylcarboxyamide HIV-1 Pr Inhibitors: Synthesis, Molecular Modeling and …
R D'Orsi, M Funicello, T Laurita, P Lupattelli, F Berti… - Biomolecules, 2021 - mdpi.com
Here, we report the synthesis, enzyme inhibition and structure–activity relationship studies of
a new potent class of HIV-1 protease inhibitors, which contain a pseudo-symmetric …
a new potent class of HIV-1 protease inhibitors, which contain a pseudo-symmetric …
Heterocyclic architecture for the synthesis of anti-HIV protease and anti-cancer compounds
R D'Orsi - 2020 - elea.unisa.it
Introduction of heterocycle moieties in a bioactive molecule can have important effects on
physicochemical and pharmacological properties, because of their chemical stability, their …
physicochemical and pharmacological properties, because of their chemical stability, their …