Introduction: About 20 patents have been published from 2013 to 2018 for developing
advanced cancer therapeutics by targeting tubulin polymerization. Currently, there are …

Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the
use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side …

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. More
effective and less toxic therapies are urgently needed for high-risk patients. Peptide-guided …

Cancer is one of the life-threatening diseases accountable for millions of demises globally.
The inadequate effectiveness of the existing chemotherapy and its harmful effects has …

A series of certain benzyl/phenethyl thiazolidinone-indole hybrids were synthesized for the
study of anti-proliferative activity against A549, NCI-H460 (lung cancer), MDA-MB-231 …

Rhabdomyosarcoma (RMS) is a highly metastatic soft-tissue sarcoma that often develops
resistance to current therapies, including vincristine. Since the existing treatments have not …

Abstract Novel series of thiopyrano [2, 3-d] 1, 3-thiazole derivatives incorporating
arylsulfonate moiety were synthesized and characterized by 1 H NMR, 13 C NMR, MS, and …

Abstract A new set of 1, 3-benzodioxoles and 1, 4-benzodioxines was designed and
synthesized starting from gallic acid as anticancer agents. The antiproliferative effect of the …

With great advances in cancer detection and treatment, patient survival rates have improved
substantially. Subsequently, significant efforts are now focused on improving the long-term …

Microtubule dynamics are crucial for multiple cell functions, and cancer cells are particularly
sensitive to microtubule-modulating agents. Here, we describe the design and synthesis of a …