Intelligent nanomaterials for medicine: carrier platforms and targeting strategies in the context of clinical application
Nanomedical approaches are a major transforming factor in medical diagnosis and
therapies. Based on important earlier work in the field of liposomal drug delivery and …
therapies. Based on important earlier work in the field of liposomal drug delivery and …
MUC1 and metastatic cancer: expression, function and therapeutic targeting
TM Horm, JA Schroeder - Cell adhesion & migration, 2013 - Taylor & Francis
MUC1 is a transmembrane mucin that is often overexpressed in metastatic cancers and
often used as a diagnostic marker for metastatic progression. The extracellular domain of …
often used as a diagnostic marker for metastatic progression. The extracellular domain of …
An effective peptide-based platform for efficient exosomal loading and cellular delivery of a microRNA
Exosomes, membrane-bound nanosized vesicles of biologic origin, are known to contain
various molecules, eg, proteins, lipids, and nucleic acids, which contribute to the exosomes' …
various molecules, eg, proteins, lipids, and nucleic acids, which contribute to the exosomes' …
The different interactions of lysine and arginine side chains with lipid membranes
L Li, I Vorobyov, TW Allen - The journal of physical chemistry B, 2013 - ACS Publications
The basic amino acids lysine (Lys) and arginine (Arg) play important roles in membrane
protein activity, the sensing of membrane voltages, and the actions of antimicrobial, toxin …
protein activity, the sensing of membrane voltages, and the actions of antimicrobial, toxin …
Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides
L Reveret, M Leclerc, F Morin, V Émond, F Calon - Scientific Reports, 2023 - nature.com
Cell-penetrating peptides (CPPs) have been used in basic and preclinical research in the
past 30 years to facilitate drug delivery into target cells. However, translation toward the …
past 30 years to facilitate drug delivery into target cells. However, translation toward the …
The pharmacokinetics of cell-penetrating peptides
D Sarko, B Beijer, R Garcia Boy… - Molecular …, 2010 - ACS Publications
Cell-penetrating peptides (CPPs) are able to penetrate the cell membrane carrying cargoes
such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and …
such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and …
Flexible or fixed: a comparative review of linear and cyclic cancer-targeting peptides
Peptides can serve as versatile cancer-targeting ligands and have been used for clinically
relevant applications such as cancer imaging and therapy. A current and long-standing …
relevant applications such as cancer imaging and therapy. A current and long-standing …
Significant enhancement of fibroblast migration, invasion, and proliferation by exosomes loaded with human fibroblast growth factor 1
Exosomes possess several inherent properties that make them ideal for biomedical
applications, including robust stability, biocompatibility, minimal immunogenicity, and the …
applications, including robust stability, biocompatibility, minimal immunogenicity, and the …
Cell-Penetrating Peptides, PepFects, Show No Evidence of Toxicity and Immunogenicity In Vitro and In Vivo
J Suhorutsenko, N Oskolkov, P Arukuusk… - Bioconjugate …, 2011 - ACS Publications
Cell-penetrating peptide based vehicles have been developed for the delivery of different
payloads into the cells in culture and in animals. However, several biological features …
payloads into the cells in culture and in animals. However, several biological features …
Viral and other cell-penetrating peptides as vectors of therapeutic agents in medicine
Efficient delivery of heterologous molecules for treatment of cells is a great challenge in
modern medicine and pharmacology. Cell-penetrating peptides (CPPs) may improve …
modern medicine and pharmacology. Cell-penetrating peptides (CPPs) may improve …