Androgen deprivation therapy (ADT) is considered as the standard therapy for men with de
novo or recurrent metastatic prostate cancer. ADT commonly leads to initial biochemical and …

Prostate cancer (PCa) is the most diagnosed malignancy in the men worldwide. Cancer
stem cells (CSCs) are the sub-population of cells present in the tumor which possess unique …

Androgen/androgen receptor (AR) signaling plays important roles in normal liver function
and in progression of liver diseases. In studies of noncancerous liver diseases, AR knockout …

Considerable levels of testosterone and dihydrotestosterone (DHT) are found In prostate
cancer (PCa) tissue after androgen deprivation therapy. Treatment of surviving cancer …

Prostate cancer is the second most frequently diagnosed cancer in the world. Localized
disease can be effectively treated with radiation therapy or radical prostatectomy. However …

Castration is the standard therapy for advanced prostate cancer (PC). Although this
treatment is initially effective, tumors invariably relapse as incurable, castration-resistant PC …

The cancer stem cell (CSC) model proposes that cells within a tumor are organized in a
hierarchical lineage relationship and display different tumorigenic potential, suggesting that …

Emergence of androgen-independent cancer cells during androgen deprivation therapy
presents a significant challenge to successful treatment outcomes in prostate cancer …

Breast cancer mortality is primarily due to the occurrence of metastatic disease. We have
identified a novel potential therapeutic agent derived from an edible root of the plant …

Androgen deprivation therapy (ADT) has been the standard care for patients with advanced
prostate cancer (PC) since the 1940s. Although ADT shows clear benefits for many patients …