Evolution in the field of the total synthesis of natural products has led to exciting
developments over the last decade. Numerous chemoselective and enantioselective …

Recent progress in the research and development of industrially and medically relevant
oxidoreductases is reviewed. Currently, the industrial-technical, food, and environmental …

Abstract The Diels–Alder reaction is one of the most powerful and widely used methods in
synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the …

The Diels-Alder reaction is a cornerstone in organic synthesis, forming two carbon-carbon
bonds and up to four new stereogenic centers in one step. No naturally occurring enzymes …

Self-assembled, hollow molecular structures are appealing as synthetic hosts for mediating
chemical reactions. However, product binding has inhibited catalytic turnover in such …

Abstract Tandem Diels–Alder reactions are frequently used in the construction of polycyclic
ring systems in complex organic compounds. Unlike the many Diels− Alderases (DAases) …

Abstract The Diels–Alder reaction is a [4+ 2] cycloaddition reaction in which a cyclohexene
ring is formed between a 1, 3-diene and an electron-deficient alkene via a single pericyclic …

The widespread adoption of biocatalysis by industry to perform highly selective chemical
syntheses has been made possible only by the development of highly effective methods in …

The Diels–Alder reaction, a [4+ 2] cycloaddition of a conjugated diene to a dienophile, is one
of the most powerful reactions in synthetic chemistry. Biocatalysts capable of unlocking new …

Application of combined quantum and molecular mechanical (QM/MM) methods focuses on
predicting activation barriers and the structures of stationary points for organic and …