Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Molecular mechanisms of neuroinflammation in aging and Alzheimer's disease progression

FL Andronie-Cioara, AI Ardelean… - International journal of …, 2023 - mdpi.com
Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Curcumin's nanomedicine formulations for therapeutic application in neurological diseases

B Salehi, D Calina, AO Docea, N Koirala… - Journal of Clinical …, 2020 - mdpi.com
The brain is the body's control center, so when a disease affects it, the outcomes are
devastating. Alzheimer's and Parkinson's disease, and multiple sclerosis are brain diseases …

Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
In last two decades, the lipid nanocarriers have been extensively investigated for their drug
targeting efficiency towards the critical areas of the human body like CNS, cardiac region …

[HTML][HTML] Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design

M Agrawal, S Saraf, M Pradhan, RJ Patel… - Biomedicine & …, 2021 - Elsevier
Herbal antioxidant like curcumin holds great potential to treat neurodegenerative disease
like Alzheimer's disease. However, its therapeutic potency is obstructed due to rapid …

Role of natural products for the treatment of Alzheimer's disease

T Noori, AR Dehpour, A Sureda… - European journal of …, 2021 - Elsevier
Negative psychological and physiological consequences of neurodegenerative disorders
represent a high social and health cost. Among the neurodegenerative disorders …

Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) as food-grade nanovehicles for hydrophobic nutraceuticals or bioactives

CH Tang, HL Chen, JR Dong - Applied Sciences, 2023 - mdpi.com
Although solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have
been successfully used as drug delivery systems for about 30 years, the usage of these …

Nanoformulations to enhance the bioavailability and physiological functions of polyphenols

B Yang, Y Dong, F Wang, Y Zhang - Molecules, 2020 - mdpi.com
Polyphenols are micronutrients that are widely present in human daily diets. Numerous
studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and …

Curcumin and its derivatives as theranostic agents in Alzheimer's disease: The implication of nanotechnology

U Shabbir, M Rubab, A Tyagi, DH Oh - International Journal of Molecular …, 2020 - mdpi.com
Curcumin is a polyphenolic natural compound with diverse and attractive biological
properties, which may prevent or ameliorate pathological processes underlying age-related …

Oxidative stress: A target to treat Alzheimer's disease and stroke

S Briyal, AK Ranjan, A Gulati - Neurochemistry International, 2023 - Elsevier
Oxidative stress has been established as a well-known pathological condition in several
neurovascular diseases. It starts with increased production of highly oxidizing free-radicals …